Corpus Hippocraticum, Aphorisms 1.6.2
Ἐς δὲ τὰ ἔσχατα νουσήματα
αἱ ἔσχαται θεραπεῖαι
ἐς ἀκριβείην, κράτισται -> For extreme diseases, extreme methods of cure, as to restriction, are most suitable.
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