chiefly
Ἐς δὲ τὰ ἔσχατα νουσήματα αἱ ἔσχαται θεραπεῖαι ἐς ἀκριβείην, κράτισται -> For extreme diseases, extreme methods of cure, as to restriction, are most suitable.
Corpus Hippocraticum, Aphorisms 1.6.2
P. and V. μάλιστα, οὐχ ἥκιστα.
for the most part: P. ὡς ἐπὶ τὸ πολύ.