סָגַר

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Ἐς δὲ τὰ ἔσχατα νουσήματα αἱ ἔσχαται θεραπεῖαι ἐς ἀκριβείην, κράτισται → But for extreme illnesses, extreme remedies, applied with severe exactitude, are the best (Hippocrates, Aphorism 6)

Source

English (Strong)

a primitive root; to shut up; figuratively, to surrender: close up, deliver (up), give over (up), inclose, X pure, repair, shut (in, self, out, up, up together), stop, X straitly.