סָגַר
From LSJ
Ἐς δὲ τὰ ἔσχατα νουσήματα αἱ ἔσχαται θεραπεῖαι ἐς ἀκριβείην, κράτισται → But for extreme illnesses, extreme remedies, applied with severe exactitude, are the best (Hippocrates, Aphorism 6)
English (Strong)
a primitive root; to shut up; figuratively, to surrender: close up, deliver (up), give over (up), inclose, X pure, repair, shut (in, self, out, up, up together), stop, X straitly.