detrimentosus
From LSJ
Ἐς δὲ τὰ ἔσχατα νουσήματα αἱ ἔσχαται θεραπεῖαι ἐς ἀκριβείην, κράτισται → But for extreme illnesses, extreme remedies, applied with severe exactitude, are the best (Hippocrates, Aphorism 6)
Latin > English (Lewis & Short)
dētrīmentōsus: a, um, adj. detrimentum,
I hurtful, detrimental: ab hoste discedere detrimentosum esse existimabat, Caes. B. G. 7, 33.