ἐς δὲ τὰ ἔσχατα νουσήματα αἱ ἔσχαται θεραπεῖαι ἐς ἀκριβείην, κράτισται → for extreme diseases, extreme methods of cure, as to restriction, are most suitable (Corpus Hippocraticum, Aphorisms 1.6.2)
fixed, appointed: P. and V. προκείμενος.
obstinate: P. and V. αὐθάδης, σκληρός.
